Duration of Mesh inflammation

This topic has 2 replies, 3 voices, and was last updated 2 years, 3 months ago by Good intentions.

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- 05/28/2021 at 7:00 am #29229
  
  Alephy
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  I am just wondering, how long does the inflammation process caused by the mesh implant last? months? years? for ever?
  
  I am not talking about chronic pain (although the two are probably correlated), but the body reaction to it, whether one has symptoms or not…
- 05/28/2021 at 11:47 pm #29230
  
  JamesDoncaster
  Participant
  
  I think another way to phrase your question would be: at what point does your body stop “fighting” the foreign body that has been placed inside of it and just “accept” it? My guess is the answer is: never. If your body recognizes something as foreign when it is first placed inside of you, what physiological change would, at some point, convince your body to accept it?
- 05/29/2021 at 11:18 am #29232
  
  Good intentions
  Participant
  
  Forever seems to be the answer. The research in to the absorbable/resorbable biologic materials is done in the hope that the FBR will destroy/replace the foreign biologic material and replace it with human tissue that is strong enough to function properly.
  
  https://link.springer.com/article/10.1007/s00423-011-0780-0
  
  “Abstract
  Mesh biocompatibility is basically determined by the foreign body reaction (FBR). In contrast to physiological wound healing and scar formation, the FBR at the host-tissue/biomaterial interface is present for the lifetime of the medical device. The cellular interactions at the mesh/tissue interface proceed over time ending up in a chronic inflammatory process. ”
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